Lab Testing · Blood draw
Methylation Health Panel
A blood panel covering the methylation pathway and MTHFR variants — the machinery your body uses to process folate, B12 and homocysteine.
A member of the care team speaks with you before anything is ordered. The price above is the full cost of the test — there is nothing to add later.
Mechanism
One pathway, many jobs.
Methylation is a chemical process your cells run constantly: attaching methyl groups to DNA, neurotransmitters, hormones and toxins so they can be regulated or cleared.
Common variants in the MTHFR gene change how efficiently that pathway runs. The panel measures the markers that show how yours is actually functioning, alongside the genetics — function and genotype together say more than either alone.
It is a diagnostic panel, not a treatment. What it changes is which form of folate or B12 your provider suggests, and whether homocysteine is worth tracking.
Protocol
How treatment usually runs.
A typical schedule. Yours is set by your clinician after your labs come back.
| Phase | Weeks | Typical | Purpose |
|---|---|---|---|
| Order | Day 0 | Requisition issued | Your provider orders the panel. |
| Draw | Days 1–5 | Single blood draw | At a national lab near you. |
| Results | ~2 weeks | Provider review | Written interpretation, not a raw PDF. |
What to expect
Honestly, over time.
Ordered
A provider reviews your history first.
Blood draw
One visit, one draw.
Results
Reviewed with you and turned into a plan if needed.
Evidence
What the research shows.
MTHFR variants are common and affect folate metabolism to varying degrees. Their clinical significance depends on the functional markers alongside them, which is why this panel measures both.
Elevated homocysteine is an established marker associated with cardiovascular risk, and is modifiable.
Genetic results do not change. If you have had this panel before, you do not need it again.
Results vary. Clinical trial results apply only to the FDA-approved branded medication specifically identified and do not apply to compounded medications. All medications must be prescribed by a licensed provider based on medical necessity.
Safety and eligibility
Your consult and labs screen for all of the following.
- Genetics are not destiny — a variant on its own does not mean you are unwell.
- Tell your provider about any B-vitamin supplements; they move these markers.
- Not a diagnosis — results are interpreted alongside your history and symptoms.
- New York, New Jersey and Rhode Island — our main lab network does not cover these three states. Tell the care team before you book and they will arrange an alternative.
FAQ
Methylation Health Panel questions.
Probably not. It is most useful when there is something to explain — persistent fatigue, raised homocysteine on a previous panel, or a family history that makes the pathway worth checking.
No. Consumer kits report genotype only. This panel measures the functional markers as well, which is what tells your provider whether the pathway is actually underperforming.
The genetic portion never changes. The functional markers move, and are worth repeating if you act on them.
We will not prescribe before we understand you.
Book a one-to-one consult with the clinical team. We talk through your goals, order the bloodwork that matters, and build a plan from what we find.