Hormones · Fertility-sparing
Enclomiphene
Raises your own testosterone production instead of replacing it, the option for men who want higher levels and still want children.
Already know this is what you want? The second option books the appointment straight away. Not sure yet? See the labs first.
Your consult is free. We will not prescribe this, or anything, before a clinician has spoken with you. Final cost depends on the form and dose prescribed.
Mechanism
Signal up, don't substitute.
Enclomiphene blocks estrogen receptors in the pituitary, which increases LH and FSH output and tells the testes to produce more testosterone themselves.
Because production is stimulated rather than replaced, testicular function and sperm production are preserved, the opposite of what conventional TRT does.
It is a tablet rather than an injection, and it is not FDA-approved for this use.
Protocol
How treatment usually runs.
A typical schedule. Yours is set by your clinician, and adjusted as you go.
| Phase | Weeks | Typical | Purpose |
|---|---|---|---|
| Baseline | Week 0 | Labs only | Total and free testosterone, LH, FSH, estradiol. |
| Start | 1–6 | 12.5–25 mg daily or alternate days | Conservative start. |
| Recheck | 6–8 | Repeat labs | Confirms the pituitary is responding. |
| Maintenance | 9+ | Adjusted to response | Ongoing monitoring. |
What to expect
Honestly, over time.
Levels climb
Testosterone typically begins rising in the first month.
Symptoms respond
Energy and libido often follow the lab change.
Confirm
Repeat labs verify the response is sustained.
Fertility preserved
Sperm production continues, unlike on TRT.
Evidence
What the research shows.
Enclomiphene raises endogenous testosterone while maintaining sperm concentration, which conventional testosterone therapy does not.
It is not FDA-approved for this indication and is prescribed off-label.
Results vary. Clinical trial results apply only to the FDA-approved branded medication specifically identified and do not apply to compounded medications. All medications must be prescribed by a licensed provider based on medical necessity.
Safety and eligibility
Your consult and labs screen for all of the following.
- Not appropriate for primary testicular failure, it requires a responsive pituitary–testicular axis.
- Tell your provider about any history of blood clots or visual disturbance.
- Common side effects include headache, nausea and mood change.
- Not FDA-approved for this use, prescribed at your provider's discretion.
FAQ
Enclomiphene questions.
For men who want to preserve fertility, generally yes, it raises your own production rather than replacing it. For men with primary testicular failure it will not work, because it depends on the testes being able to respond.
It preserves it. Unlike testosterone therapy, which suppresses sperm production, enclomiphene stimulates the natural signalling pathway and typically maintains or improves sperm concentration.
Testosterone levels usually begin rising within two to four weeks, with symptom improvement following. Repeat labs at six to eight weeks confirm the response.
We will not prescribe before we understand you.
Book a one-to-one consult with the clinical team. We talk through your goals, order the bloodwork that matters, and build a plan from what we find.