Sleep & Recovery
DSIP Injection
Delta Sleep-Inducing Peptide, taken nightly, is studied for its potential role in sleep regulation — intended for patients whose sleep hasn't responded to simpler measures.
This is a compounded preparation made by a licensed pharmacy. It is not FDA-approved, and it is prescribed only when a licensed provider determines it is appropriate for you.
Already know this is what you want? The second option books the appointment straight away. Not sure yet? See the labs first.
Your consult is free. We will not prescribe this, or anything, before a clinician has spoken with you. Final cost depends on the form and dose prescribed.
Mechanism
Signal sleep, don't sedate.
DSIP (Delta Sleep-Inducing Peptide) was first identified in research into brain electrical activity during deep sleep. It's studied for a possible role in regulating sleep-wake signaling rather than acting as a direct sedative.
Unlike many prescription sleep aids, DSIP is not a benzodiazepine or a classic hypnotic, which is part of why some providers consider it for patients looking for a different approach to sleep support.
It's generally dosed at night and often cycled with breaks rather than used continuously for extended periods.
Protocol
How treatment usually runs.
A typical schedule. Yours is set by your clinician, and adjusted as you go.
| Phase | Weeks | Typical | Purpose |
|---|---|---|---|
| Start | 1–2 | Low dose nightly before bed | Subcutaneous injection, 30–60 minutes before sleep. |
| Build | 3–6 | Standard nightly dose | Adjusted based on sleep response. |
| Cycle / Reassess | 7–8 | Often cycled, e.g. 5 days on, 2 off | Continued use reviewed with your provider. |
What to expect
Honestly, over time.
Early response
Some patients report changes in sleep onset or quality early on.
Pattern forms
Sleep quality trends typically become clearer over several weeks.
Cycle review
Your provider reassesses continued use, cycling or discontinuation.
Evidence
What the research shows.
Research on DSIP in humans is limited and dates back decades in small studies; it has not been evaluated in large, modern controlled trials for sleep disorders. Reported sleep benefits are largely based on patient-reported experience rather than robust clinical evidence.
Results vary. Clinical trial results apply only to the FDA-approved branded medication specifically identified and do not apply to compounded medications. All medications must be prescribed by a licensed provider based on medical necessity.
Safety and eligibility
Your consult and labs screen for all of the following.
- Do not use if you have a known hypersensitivity to the compound or are currently using other sedative-hypnotic medications without your provider's knowledge.
- Tell your provider about any diagnosed sleep disorder, mood disorder, or medications that affect sleep or the central nervous system.
- Common side effects include injection-site reaction, vivid dreams and next-morning grogginess.
- Not FDA-approved for this use — prescribed at your provider's discretion.
FAQ
DSIP Injection questions.
DSIP, or Delta Sleep-Inducing Peptide, is studied for a possible role in regulating sleep-wake signaling. It isn't a sedative in the way prescription sleep medications are.
It's usually injected nightly before bed, often on a schedule like five days on and two off, with your provider reviewing continued use every several weeks.
Some patients report early changes within the first few nights, but a clearer pattern in sleep quality usually takes two to four weeks to assess.
Related
Often part of the same plan.
Sermorelin
Nightly injection
